Penicillium marneffei infections youngstown state university. Pdf penicillium marneffei infection in aids researchgate. Penicillium marneffei an overview sciencedirect topics. This report describes the use of fine needle aspiration fna cytology to make a rapid diagnosis of penicillium marneffei infection in an hiv positive patient. Histopathologic diagnosis of fungal infections in the 21st. Talaromyces marneffei formerly penicillium marneffei is an important cause of morbidity and mortality in hivinfected and other immunosuppressed patients who live in or are from southeast asia, and can occasionally cause disease in such patients who have had travelrelated exposure to this organism. Diagnostic cytology and morphometry of penicillium marneffei. In vitro at 37c the yeast form which seems to be an arthroconidia is unicellular, oval or elongated, it does not reproduce by budding as most yeasts but by fission. Lymphadenopathy due to penicillium marneffei infection. Clinicopathologic study of hepatic penicillium marneffei in. Penicillium marneffei is a rare fungal pathogen which can cause humaninfections in people predominantly living in southeast asia and the southern portion of china. A case of penicillium marneffei osteomyelitis involving the axial skeleton ts pun, d fang fungal infection of bone by penicillium marneffei is rare. Notes for figure 3, please refer to the welcome and contributing authors page for the list of idsa 2003 contributors. A h jeffrey, mmed, a l mohamed phd, department of medicine, faculty of medicine, hospital universiti kebangsaan malaysia, jalan tenteram, 56000 cheras, kuala lumpur case report a 48 year old vegetable farmer was admitted to the.
Endemic in southeast asia, it infects 10% of aids patients in this region. Penicillium marneffei is a well described aids defining pathogen in south east asia but is very rare in the uk. There are a few case reports of xa diagnosed on histopathology but. Penicillium marneffei is an endemic fungus in southeast asia that causes deepseated infection in humans and rodents. The clinical presentation and histopathologic findings in p. Persons affected by penicilliosis usually have aids with. Specific identification of penicillium marneffei by a polymerase chain. Penicillium marneffei is an opportunistic fungal infection that usually causes disseminated disease, mainly in immunocompromised individuals, especially those with hiv infection. Penicilliosis is an infection caused by penicillium marneffei, a dimorphic fungus endemic to southeast asia and the southern part of china. Penicillium marneffei was first reported in vietnam in 1956, following its isolation from the liver of a bamboo rat rhizomys sinensis that died of disseminated infection.
Penicillium marneffei, wright stain of skin lesion specimen. Pdf histopathological and electron microscopical studies on. Penicillium marneffei is a rare human pathogen predominantly affecting residents of south. Hivinfected patients, but intestinal penicilliosis marneffei has rarely been. It is a particularly important cause of disease due to weakened immunity i. We describe a patient with sle who was infected by the fungus penicillium marneffei. Cultures of talaromyces marneffei may represent a biohazard to laboratory personnel and should be handled with caution in a class ii biological safety cabinet bscii. We report four fatal cases from hong kong in human immunodeficiency virus. Diagnostic cytology and morphometry of penicillium marneffei in the sputum of a hypogammaglobulinemia with hyperigm patient. Penicillium marneffei infection in a patient with sle c. Cytological diagnosis of penicillium marneffei infection ishiow jan, 1pingfung chung, jannyuan wang,2 minghsiang weng, chienching hung,2 lina lee1,2 backgroundpurpose.
Article pdf available in pathology research international 201. Unusual pulmonary manifestations of disseminated penicillium. We report on a case of penicillium marneffei infection in a filipino woman, which involved multiple softtissue abscesses and infection of the axial skeleton. Disseminated penicillium marneffei infection in hiv. The majority of infections have been reported in immunosuppressed patients infected with hiv. Penicillium is a very large and ubiquitous genus which currently contains 354 accepted species visagie et al. Talaromycosis previously referred to as penicilliosis was commonly diagnosed in hivinfected individuals from endemic areas prior to the era of potent antiretroviral therapy art, and was an important cause of morbidity and mortality. Histopathological and electron microscopical studies on experimental. Penicillium marneffei infection in a non aids patient. Penicillium marneffei was renamed talaromyces marneffei in 2015, and the. She died four days after admission, while still under investigation. Mar 15, 2003 penicillium marneffei is a dimorphic fungus that intracellularly infects the reticuloendothelial system of humans and bamboo rats. With the prevalence of aids in this area, the number of patients with systemic penicilliosis marneffei is found to be increasing rapidly in mainland china in recent years. Exploring the penicillium marneffei genome springerlink.
Pathology of penicilliosis penicillium marneffei infection. Rarely noted before the aids epidemic, p marneffei infections have become more prevalent in the endemic areas in conjunction with the aids epidemic. The name of the fungus and the name of the infection have changed. Many species are common contaminants on various substrates and are known as potential mycotoxin producers. Talaromycosis formerly penicilliosis fungal diseases cdc. The absence of a sexual stage and the highly infectious nature of the mouldphase conidia have impaired studies on thermal dimorphic switching and hostmicrobe interactions. Penicillium marneffei penicilliosis infectious disease.
Warnock dw ed, manual of clinical microbiology, vol 11. Penicillium marneffei is a dimorphic fungus that has been identified as an. Penicillium marneffei on gram stain of blood culture. A case of penicillium marneffei osteomyelitis involving.
Fungus is hyaline hyphomycetes, related to aspergillus university of adelaide. Penicillium marneffei infection in patients infected with the human immunodeficiency virus. Penicillium marneffei is a dimorphic fungus whose endemicity is limited to south eastern and far eastern asia. Penicilliosis is caused by penicillium marneffei, a ubiquitous saprophyte of soil and decomposing organic matter.
Pdf in recent years, fungi have emerged as a major public health problem both in developed. Penicillium images partners infectious disease images. It is an opportunistic pathogen which has emerged to become an aidsdefining illness in the endemic areas. Talaromycosis is an infection caused by the fungus talaromyces marneffei. Postmortem examination revealed antibodies to human immunodeficiency virus, disseminated penicillium marneffei infection, and salmonella enteritidis infection. Vanittanakom n, cooper r, fisher m, sirisanthana t, penicillium marneffei vanittanakom n, cooper r, fisher m, sirisanthana t, penicillium marneffei. A disseminated and progressive infection, penicilliosis marneffei is the third most common opportunistic fungal infection in human immunodeficiency virus hivinfected patients in certain parts of southeast asia. Penicillium marneffei is a dimorphic fungus which is endemic in southeast asia.
Penicillium marneffei is a rare human pathogen that often causes problems in clinical and histological diagnosis. She was initially misdiagnosed as having disseminated tuberculosis. Pdf histopathological and electron microscopical studies. Pneumonia caused by talaromyces marneffei journal of clinical. The pathology of penicilliosis in different organs varies depending on the.
Read disseminated penicillium marneffei infection in hiv. Penicillium marneffei infection is an important emerging public health problem, especially among patients infected with human immunodeficiency virus in the areas of endemicity in southeast asia, india, and china. Department of pathology, the first affiliated hospital, zhejiang. A patient who presented with autoimmune haemolytic anaemia and hepatosplenomegaly, and was subsequently found to be suffering from disseminated penicillium marneffei infection, is reported. Massive hepatosplenomegaly caused by penicillium marneffei. Talaromyces marneffei formerly penicillium marneffei causes a systemic fungal infection referred to as talaromycosis. Summary penicillium marneffei infection is an important emerging public health problem, especially among patients infected with human immunodeficiency virus in the areas of endemicity in southeast asia, india, and china. Talaromyces marneffei, formerly called penicillium marneffei, discovered in 1956, is now regarded as one of the worlds ten most feared fungi. Major endemic mycosis of aids patients in southeast asia, china, hong kong and taiwan almost always systemic with fever, weight loss and anemia. Because histopathologic examination of tissues detects fungal invasion of tissues and vessels as well as the host reaction to the fungus, it is and will remain an important tool to define the diagnostic significance of. Early diagnosis with prompt initiation of treatment is crucial for its management.
Penicillium marneffei infection and recent advances in the. Penicillium marneffei is a dimorphic fungus that causes one of the most common opportunistic infections in asian patients with aids. Fungal infections are becoming more frequent because of expansion of atrisk populations and the use of treatment modalities that permit longer survival of these patients. Cytological diagnosis of penicillium marneffei infection. Pdf experimental penicillium marneffei infection in mice was investigated histopathologically and by electron microscopy. Talaromyces marneffei an overview sciencedirect topics.
Sep 17, 2012 penicillium marneffei is an emerging pathogenic fungus that can cause a lifethreatening systemic mycosis in immunocompromised hosts, especially in patients with aids. Correct identification is therefore important when studying possible penicillium contamination of food. Among such fungi, penicillium marneffei segretain, the principal cause of penicillosis, is a. Keywords penicillium marneffei, talaromyces marneffei, penicilliosis, talaromycosis. Penicillium marneffei is a dimorphic fungus which is endemic in. Penicillium marneffei infection in patients with aids. Rapid diagnosis of penicillium marneffei infection by fine.
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